Fever by Robin Cook

tinkle of glass and the sound of fluid. When the doctor turned, he had a wet piece of cotton in each hand. “I’m just going to clean your skin a little,” he explained as he began scrubbing Michelle’s hipbone.
    The water felt alarmingly cold to Michelle as it ran down her hip and pooled beneath her buttocks. This was a new experience, not like the previous needles. She strained to see what was happening, but the doctor gently urged her to lie back.
    â€œIt will be over in just a moment,” said Miss Hammersmith.
    Michelle looked at the faces of the nurses. They were allsmiling but they were fake smiles. Michelle began to feel panic. “Where are you going to stick me?” she shouted, trying again to sit up.
    As soon as she moved, she felt strong arms grip her and force her back. Even her ankles were locked in an iron grasp. She was pressed firmly back onto the table, and the restriction inflamed her panic. She tried to struggle but felt the hold on her limbs tighten. “No!” cried Michelle.
    â€œEasy now,” said Dr. Wiley as he floated a gun-metal colored drape with a hole in the center over Michelle’s pelvis and positioned it on her hipbone. Turning back to the small table, Dr. Wiley busied himself. When he reappeared in Michelle’s view he was holding a huge syringe with three stainless steel finger rings.
    â€œNo!” cried Michelle and with all her might she tried to break from the grasp of the nurses. Instantly she felt the crushing weight of Miss Hammersmith settle on her chest, making breathing difficult. Then she felt the sharp pain of a needle pierce her skin over her hipbone followed by a burning sensation.
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    Charles bit off the corner of his pastrami on white, catching a stray piece of meat with his fingers before it fell to the desktop. It was a mammoth sandwich, the only good thing put out by the institute cafeteria. Ellen had brought it back to the lab since Charles did not want to see anyone and, except for his brief foray to the First National Bank, he’d stayed at his desk poring over the Canceran experimental protocol. He’d been through all the lab books, and to his surprise, he found them well-organized. He began to feel optimistic that completing the study would not be as difficult as he had initially imagined; maybe they could get it done in six months. He swallowed what he had in his mouth and chased it down with a slug of lukewarm coffee.
    â€œThe one good thing about this project,” said Charles, wiping his mouth with the back of his hand, “is the size of the grants. For the first time we’ve got money to burn. I’ll bet wecan get that new automatic counter we’ve wanted as well as a new ultra centrifuge.”
    â€œI think we should get a new chromatography unit,” said Ellen.
    â€œWhy not?” said Charles. “Having been railroaded into this project, we owe it to ourselves.” He put the sandwich back down on the paper plate and picked up his pencil. “Here’s the way we’ll handle this thing. We’ll start out with a dose of 1/16 of the LD50.”
    â€œWait,” said Ellen. “Being in immunology, it’s been a while since I’ve done this kind of thing. Refresh me. The LD50 is the dose of a drug that causes 50 percent death in a large population of test animals. Right?”
    â€œRight,” said Charles. “We have the LD50 for mice, rats, rabbits, and monkeys from the toxicity studies done on Canceran before they started the efficacy studies. Let’s start out with the mice. We’ll use the RX7 strain bred for mammary tumors because Brighton ordered them and they’re here.”
    With his pencil, Charles began to make a flow diagram of the project. While he wrote, he spoke, explaining to Ellen each step, particularly how they would increase the dosage of the drug and how they would expand the study to include rats and rabbits as soon as they got